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My mother has had major depressive disorder for over 45 years. She was taking Orap and fluoxetine for most of that time, but the Orap was causing Parkinson's-like symptoms. Discontinuing Orap can produce other symptoms, of which my mother had chomping of her jaw, and excess salivation. Abilify controlled these other symptoms, but did nothing for her depression, resulting in auditory hallucinations. My mother was switched to olanzapine which is controlling the depression symptoms. She is currently taking 2.5mg upon waking, 2.5mg in mid-afternoon, and 7.5mg at bedtime. Olanzapine causes sleepiness, so normally would be taken only at night, but the daytime dosages were in hopes of controlling the post-Orap symptoms.



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