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This medicine is like playing a game. "Side effect Roulette". It is a quality of life issue. Yes, it may extend your life, but it makes you misearble while you are getting there. Hot Flashes, Severe Sweating, Insomnia, Severe Constipation, NO Menstrual Periods, it has stopped it completely, Bone Pain, Light Headness, unsteadiness, nausea....I fear what I am going to experience next. This constipation HAS to go.

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Between March 3, 2003, and Feb 8, 2012, we enrolled 2980 postmenopausal women from 236 centres in 14 countries and randomly assigned them to receive anastrozole (1449 analysed) or tamoxifen (1489 analysed).

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The evidence, as described below, indicates that sequential tamoxifen and AI is superior to remaining on tamoxifen for 5 years.

Other molecular biomarkers may also be used to select appropriate patients likely to benefit from tamoxifen.

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Some breast cancer survivors are treated with drugs known as aromatase inhibitors to help prevent recurrence, but a common side effect of these drugs is joint pain and stiffness.

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